G-418遗传霉素 G-418 Sulfate, Geneticin

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MG9028

G-418遗传霉素 G-418 Sulfate, Geneticin

108321-42-2	500MG	280.00	In stock
108321-42-2	1G	420.00	In stock
108321-42-2	5G	1480.00	In stock

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产品概述
Molecular Weight : 692.71 Molecular Formula : C20H40N4O10 ·2H2SO4 Appearance : white powder Moisture : ≤3% Potency : > 730 ug/mg Purity : ≥ 98% Introduction G-418 sulfate has originally been derived from Micromonospora rhodoranga NRRL 5326. G-418 sulfate is an aminoglycosidic antibiotic, it acts by interfering with protein synthesis and is usually used as an agent for selection of cultured cells expressing a gene that confers resistance to G-418. It is toxic to both prokaryotic and eukaryotic cells. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that Geneticin Sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosomes and inhibits the elongation cycle. Further studies report that Geneticin Sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells. Storage condition Dry powder should be stored at 2-8℃ and solution at -20℃. For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

产品概述

Molecular Weight : 692.71
Molecular Formula : C20H40N4O10 ·2H2SO4

Appearance : white powder
Moisture : ≤3%

Potency : > 730 ug/mg
Purity : ≥ 98%

Introduction
G-418 sulfate has originally been derived from Micromonospora rhodoranga NRRL 5326. G-418 sulfate is an aminoglycosidic antibiotic, it acts by interfering with protein synthesis and is usually used as an agent for selection of cultured cells expressing a gene that confers resistance to G-418. It is toxic to both prokaryotic and eukaryotic cells. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that Geneticin Sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosomes and inhibits the elongation cycle. Further studies report that Geneticin Sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells.

Storage condition
Dry powder should be stored at 2-8℃ and solution at -20℃.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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