BMS-1
产品货号 产品名称 CAS号 包装 市场价(人民币) 库存状态
MPI0923 BMS-1
1675201-83-85mg1450.00In Stock
1675201-83-825mg3650.00In Stock
产品概述

分子式 :C29H33NO5  
分子量 :475.58
纯度 : 99.61%
产品简介:BMS-1 是 PD-1/PD-L1 蛋白质/蛋白质相互作用的抑制剂,IC50 为 6 到 100 nM。
溶解性:DMSO 95 mg/mL (199.75 mM);Water 95 mg/mL (199.75 mM);Ethanol 95 mg/mL (199.75 mM)

Description
BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM).
 
In Vitro
Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy.
 
In Vivo
BMS-1 (500 μg/mL; 100 μL; i.p.) significantly slows down tumor growth and prolongs the survival rates in BALB/c mice.
 
Animal Model : BALB/c mice
Dosage : 500 μg/mL; 100 μL
Administration : I.p.
Result : Administration significantly slowed down tumor growth and prolonged the survival rates.
 
Storage condition
-20°C
 
For Research Use Only. Not For Use In Diagnostic Procedures. 

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产品手册 MSDS COA 参考