N-草酰甘氨酸N-Oxalylglycine
产品货号 产品名称 CAS号 包装 市场价(人民币) 库存状态
MG5239 N-草酰甘氨酸N-Oxalylglycine
5262-39-510mg835.00In stock
5262-39-550mg1650.00In stock
产品概述

产品简介
α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂。
 
Molecular Weight : 147.1
Molecular Formula : C4H5NO5
Purity (HPLC)(%) ≥98
Physical Appearance: A crystalline solid
 
Description
N-Oxalylglycine, as known as NOG, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes which include JMJD2A, JMJD2C, and JMJD2E. NOG also blocks the prolyl hydroxylase domain-containing proteins PHD1 and PHD2. Demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 can be catalyzed by JMJD2 subfamily of histone demethylases. Since histone demethylases are related to certain diseases, including cancer, selective inhibitors functions as anticancer agents and potential tools for clarifying the biological functions of JMJDs.
 
In vitro: NOG was identified as a natural product and presented in plants, including Rheum rhabarbarum (rhubarb) and Spinach oleracea (spinach) leaves. However, there was no NOG observed human embryonic kidney cells (HEK 293T) or Escherchia coli. NOG regulated gene expression via blocking 2-Oxoglutarate-dependent oxygenases.
 
In vivo: Up to now, in vivo study of NOG is still in the development stage.
 
IC50: 250 μM: inhibits α-ketoglutarate-dependent enzyme jumonji domain-containing protein 2 (JMJD2) A.
IC50: 500 μM: blocks α-ketoglutarate-dependent enzyme JMJD2C.
IC50: 24 μM: dampens α-ketoglutarate-dependent enzyme JMJD2E.
IC50: 2.1 μM: suppresses the prolyl hydroxylase domain-containing proteins PHD1.
IC50: 5.6 μM: depresses the prolyl hydroxylase domain-containing proteins PHD2.
 
Solubility
≤10mg/ml in ethanol;10mg/ml in DMSO;5mg/ml in dimethyl formamide
 
Storage Condition
-20°C
 
For Research Use Only. Not For Use In Diagnostic Procedures.

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产品手册 MSDS COA 参考
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