雷帕霉素Rapamyein - 迈基生物

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雷帕霉素Rapamyein

产品货号

产品名称

CAS号

包装

市场价（人民币）

库存状态

MP5440

雷帕霉素Rapamyein

53123-88-9	10mg	420.00	In stock
53123-88-9	25mg	805.00	In stock
53123-88-9	100mg	1650.00	In stock

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产品概述
Molecular Weight : 914.2 Molecular Formula : C51H79NO13 Purity >98 % Description Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR. Storage condition -20℃ For Research Use Only. Not for use in diagnostic procedures.

产品概述

Molecular Weight : 914.2

Molecular Formula : C51H79NO13

Purity >98 %

Description

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Storage condition

-20℃

For Research Use Only. Not for use in diagnostic procedures.

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