羟苯基荧光素 HPF, Hydroxyphenyl Fluorescein

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CAS号

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市场价（人民币）

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MFH3549

羟苯基荧光素 HPF, Hydroxyphenyl Fluorescein

359010-69-8

500ug

2765.00

In stock

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产品概述
A cell permeable, fluorescent dye for detection of highly reactive oxygen species Synonym(s) : Hydroxyphenyl Fluorescein Molecular Weight : 424.40 Molecular Formula : C26H16O6 Purity ≥ 98.0% Description The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). HPF is a cell-permeable aromatic amino-fluorescein derivative that has little intrinsic fluorescence. It undergoes oxidation only by highly reactive oxygen species (hROS) such as the hydroxyl radical, peroxynitrite, and hROS generated from a peroxidase/H2O2 system. It is inert to hypochlorite ion, nitric oxide, hydrogen peroxide (H2O2), superoxide, and other oxidants. Upon oxidation, HPF is converted to the highly fluorescent molecule fluorescein, with excitation/emission maxima of 490/515 nm, respectively, allowing the simple direct detection of highly reactive biological radicals. Storage condition -20°C, protect from light For Research Use Only. Not For Use In Diagnostic Procedures.

产品概述

A cell permeable, fluorescent dye for detection of highly reactive oxygen species

Synonym(s) : Hydroxyphenyl Fluorescein

Molecular Weight : 424.40

Molecular Formula : C26H16O6

Purity ≥ 98.0%

Description

The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). HPF is a cell-permeable aromatic amino-fluorescein derivative that has little intrinsic fluorescence. It undergoes oxidation only by highly reactive oxygen species (hROS) such as the hydroxyl radical, peroxynitrite, and hROS generated from a peroxidase/H2O2 system. It is inert to hypochlorite ion, nitric oxide, hydrogen peroxide (H2O2), superoxide, and other oxidants. Upon oxidation, HPF is converted to the highly fluorescent molecule fluorescein, with excitation/emission maxima of 490/515 nm, respectively, allowing the simple direct detection of highly reactive biological radicals.

Storage condition

-20°C, protect from light

For Research Use Only. Not For Use In Diagnostic Procedures.

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