重组人表皮生长因子受体Recombinant Human Epidermal Growth Factor Receptor / EGFR / ErbB1 / HER1 (C-6His)
产品货号 产品名称 CAS号 包装 市场价(人民币) 库存状态
MGR9170 重组人表皮生长因子受体Recombinant Human Epidermal Growth Factor Receptor / EGFR / ErbB1 / HER1 (C-6His)
-10ug1200.00In stock
-50ug4860.00In stock
-500ug18050.00In stock
产品概述

Description
Recombinant Human EGFR is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a 6His tag at the C-terminus. The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.
 
Origin
Human Cells
 
Quality control
Greater than 95% as determined by SDS-PAGE.
 
Dissolution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 
Store condition
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 
For Research Use Only. Not for use in diagnostic procedures.

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产品手册 MSDS COA 参考
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